What happens in the brain during fear learning?

What happens in the brain during fear learning?

A team of researchers affiliated with multiple institutions in China and one in Germany has learned more about what happens in the brain when a person experiences fear by studying data from probes placed deep in the brains of epileptic patients. The paper is published in Science Advances.

Much research has been conducted to learn more about what happens to the body when a person experiences fear—the heart rate picks up, for example, and quite often, people start to sweat. But much less is known about what goes on in the brain during such experiences. This is because the mechanisms involved lie deep inside the brain, where it is difficult to get brain wave readings. In this new effort, the researchers overcame that difficulty by recruiting epileptic patients fitted with brain probes; the subjects completed a fear learning task.

Prior research has shown that in the brain, fear appears to originate in the amygdala and the medial prefrontal cortex (mPFC), so that was where the researchers focused. To learn more about what happens in those brain regions, the researchers showed the volunteers a square on a computer screen. At random moments, a shock to the wrist would accompany the display of a colored square, teaching the volunteer to fear that color square. The same volunteers then looked at the square again after their probes were in place.

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