(HealthDay)—Liposomal bupivacaine use in patients undergoing total knee arthroplasty is not associated with clinically meaningful reductions in inpatient opioid use, resource utilization, or opioid-related complications, according to a study published online May 21 in Anesthesiology.
Lukas Pichler, M.D., from Weill Cornell Medical College in New York City, and colleagues analyzed the impact of liposomal bupivacaine use (regardless of administration route) on inpatient opioid prescription, resource utilization, and opioid-related complications among 88,830 patients undergoing total knee arthroplasties (2013 to 2016) with a peripheral nerve block.
The researchers found that liposomal bupivacaine was used in 21.2 percent of patients. Its use was not associated with a clinically meaningful reduction in inpatient opioid prescription, length of stay, or cost of hospitalization. In addition, liposomal bupivacaine use was not associated with decreased odds of opioid-related complications.
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