Effects of antioxidants on colorectal cancer
Black tea, hot cocoa, nuts, and berries seem to contribute to create a particularly hospitable environment for mutated genes in the intestine, which speeds up the growth of colorectal cancer.
In a study with the participation of the Hebrew University-Hadassah Medical School, Jerusalem, it was found that certain foods with anti-oxidants, surprisingly, is the growth of colon cancer seem to favor. Actually protect adopted of antioxidants that have a positive effect on health, free Radicals and therefore against cancer. The groundbreaking new findings were published in the English journal “Nature”.
Why is diseases of the colon vulnerable to cancer?
Cancer in the small intestine occurs only quite rarely, whereas colon cancer in the colon, an adjacent, though much smaller Organ, one of the most common causes of cancer deaths in men and women. The researchers the question of why the large intestine is particularly vulnerable to cancer are, therefore,.
A Positive impact of cancer mutations?
In her research she found out that cancer mutations are really bad actors. In fact, these mutations can help in certain micro-environments such as the intestines the body to fight existing cancer and prevent the spread of flame.
Effects of antioxidants on the risk of cancer
As soon as the gut microbiome produces high amounts of metabolites, as in certain bacteria and antioxidants foods such as black tea, and hot cocoa happen, going to be the intestinal microbiome to a particularly hospitable environment for the growth of cancer.
What is the influence of the content of bacteria in the gut?
The researchers discovered to their own information, may also be the reason why only two percent of cancers of the colon occur in the small intestine, and 98 percent in the colon. A major difference between these two institutions, the content of intestinal bacteria In the small intestine there are only a few, in the large intestine, however, many of these bacteria.
What is the role of the p53 Protein?
The results indicate how important the role of Intestinal micro-organisms for the health of play. In some cases, can be caused by these organisms have a positive impact, in other cases, the emergence of diseases can be supported. For a more detailed explanation: TP53 is a Gene found in every cell. It produces a Protein called p53, which acts as a barrier for the cell and genetic mutations in the cell are suppressed. P53 is damaged, however, no longer protects the cell. Quite the contrary, it drives the cancer and helps tumors to spread and grow, reports the researchers.
How had p53 in the intestine?
In the study, the research group introduced mutant p53 proteins in the intestine, which is cancer of the driving should. Surprisingly, responded to the small intestine, by transforming mutant p53 in normal p53, and in so-called Super-suppressors transformed, could the cancer growth better press as a healthy p53 proteins. However, when mutant p53 was introduced into the large intestine, was not observed this effect. The Protein promoted the spread of cancer.
Gut flora played an important role in the development of cancer
To verify the theory that the intestinal flora was a major factor for why mutant p53 in the small intestine as a tumor blocker, in the colon but as a tumor accelerator were used, the researchers antibiotics, the intestinal flora of the colon to kill. This led to mutant p53 favored the development of cancer.
Foods with antioxidants speed up cancer?
The intestinal flora produces metabolites (antioxidants), which are also found in high concentrations in foods such as black tea, hot cocoa, nuts and berries. As mice with an antioxidant-rich food were fed, accelerated in the intestinal flora of cancer, in a driver mode of p53. This finding is for patients with a family history of colorectal cancer is of particular importance, report the researchers.
The should consider people with bowel cancer risk
The Team was amazed to determine the extent to which microorganisms cancer mutations affect. In some cases, they change their nature completely. People with an increased risk for colorectal cancer should let their intestinal flora is perhaps more likely to examine and carefully consider, whether the ingested food contains antioxidants, or not, advise the researchers. (as)