Through a global gene expression analysis (transcriptomic), the researchers were able to find and confirm a genetic signature common to genodermatoses in patients’ cells. The profile targets cellular activation and alteration of the dermal microenvironment (lower layer of the skin) which could favour the progression of the disease, as well as skin cancer.
Recessive dystrophic epidermolisis bullosa and Kindler syndrome are diseases that cause fragility of the skin, caused by mutations in essential genes to attach the two layers of the skin. Patients with these diseases suffer from chronic erosion and wounds on the skin and mucosa, which causes terrible scarring and metastatic squamous cell carcinoma to develop.
On the other hand, xeroderma pigmentosum is a disease characterised by high sensitivity to ultraviolet light, due to a deficiency in the DNA repair mechanisms, meaning patients are 110,000 times more likely to develop skin cancer.
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